Omics genetic score-phenotype association scan in UK Biobank

Summary

Number of phenotypes scanned: 17 (Phenome-wide association scan is coming soon)
Cohort: UK Biobank
Ancestry: White British
Testing Model for disease: Age as the time scale Cox regression models (y ~ omics genetic score* + strat(sex) + genotyping array + 10PCs)
Testing Model for continuous trait: Ordinary least squares regression (y ~ omics genetic score* + sex + age + clinical center + genotyping array + medication status** + 10PCs)
Selection criterion: FDR-adjusted p-value < 0.05

* Only traits that had a r2>0.01 in internal validation were considerred in the association tests.
** Corresponding medication statuses were used as covariates for traits applicable.

Explore and download omics genetic score-phenotype associations

Phenotype #SOMAscan Proteins #Olink Proteins #Metabolon Metabolites #Nightingale Metabolites #RNAseq Gene expression Download
Cholesterol 643 99 252 128 1446 https://app.box.com/s/x2lf30kxc2hswechaix1z478ifaun0zp
HDL 586 80 205 118 1588 https://app.box.com/s/6sinni23v8glqvv5shbnu11gxjz130s9
Systolic Blood Pressure 223 28 90 61 898 https://app.box.com/s/kr3p0sxvjxl3esr6x2h7akycsw30jf3q
Triglycerides 568 81 259 123 1341 https://app.box.com/s/p5koye633utub0pc8u3ouhmr3pylgoxy
LDL 619 92 254 124 1322 https://app.box.com/s/mmciynqbprd4o16uf1lt8ezbaufyjvkt
Ischaemic Stroke 0 0 0 0 0 https://app.box.com/s/h5ug25zx62dnhtylij25qgvmdauidhe3
Glaucoma (CALIBER) 2 0 1 0 25 https://app.box.com/s/hk9g1y1nhgdnmkf5zci6icuzcf7bl9pa
Colorectal Cancer 0 0 0 0 1 https://app.box.com/s/2btxydlyu6tqeca2hn8auekfjybwe3gj
Diastolic Blood Pressure 266 51 127 51 1030 https://app.box.com/s/oi3v2yiktnx0d29sq40jh54zr67u9h7v
Atrial Fibrillation 45 13 1 24 110 https://app.box.com/s/dce0wup7jkm1p8uwrusrqtn4zo96oz7z
Breast Cancer 7 0 4 0 14 https://app.box.com/s/pvtzvx4nnjfoqs2dus54mhhvf3m8s4ww
Stroke 0 0 0 0 1 https://app.box.com/s/r5fvfqsn7mjo6g2h6d7z78uz0j8389o7
BMI 255 46 192 114 1381 https://app.box.com/s/s001uvj3uzybsugqnhtvt8bh07rfadn0
CVD 179 41 53 109 221 https://app.box.com/s/wv4q1dbgqxk37tz9rkb665lbvt7fzump
CAD 176 36 66 112 250 https://app.box.com/s/is2ulgwpx3igjobqlpl8k7wwpb2c055v
Depression 1 0 0 0 0 https://app.box.com/s/5kqdsqdu3mu1n5y2rkhbpycke0d95bmx
T2D 96 13 31 46 256 https://app.box.com/s/svejestpd8njnkme61o27mp60utca8kq