InouyeLab: Scott Ritchie, Sam Lambert, Loïc Lannelongue, Artika Nath, Elodie Persyn
Department of Public Health and Primary Care, University of Cambridge: Bram Prins, Praveen Surendran, Dirk Paul, Adam Butterworth, John Danesh
MRC Epidemiology Unit, University of Cambridge: Maik Pietzner, Claudia Langenberg
MRC Human Genetics Unit, The University of Edinburgh: Paul Timmers, Sebastian May-Wilson, Nicola Pirastu, Jim Wilson
Immunology, Genetics and Pathology, IGP, Uppsala University: Åsa Johansson
Karolinska Institutet: Anders Mälarstig
Participants in the INTERVAL randomised controlled trial were recruited with the active collaboration of NHS Blood and Transplant England, which has supported field work and other elements of the trial. DNA extraction and genotyping was co-funded by the National Institute for Health Research (NIHR), the NIHR BioResource and the NIHR [Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust]. The academic coordinating centre for INTERVAL was supported by core funding from: NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024), UK Medical Research Council (MR/L003120/1), British Heart Foundation (SP/09/002; RG/13/13/30194; RG/18/13/33946) and the NIHR [Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust]. A complete list of the investigators and contributors to the INTERVAL trial is provided in the reference. The academic coordinating centre would like to thank blood donor centre staff and blood donors for participating in the INTERVAL trial. All participants in the ORCADES study gave written informed consent and the study was approved by Research Ethics Committees in Orkney, Aberdeen (North of Scotland REC), and South East Scotland REC, NHS Lothian (reference: 12/SS/0151).The NSPHS study was approved by the local ethics committee at the University of Uppsala (Regionala Etikprövningsnämnden, Uppsala, Dnr 2005:325) in compliance with the Declaration of Helsinki. All participants gave their written informed consent to the study. For participants of under legal age, a legal guardian also signed. UK Biobank data access was approved under project 7439, and all the participants gave their informed consent for health research.